Straight-Shooting Drill Jig
You may not face this problem often, but when you need to drill a hole nice and straight but the part is too big to fit on the drill press, here's what to do: Make this nifty little jig. It's about 1-1/2" tall by 2" wide. Line up your drill bit in the corner of the jig and get a perfectly straight hole every time.
Nice and simple. The only thing I would add is that you could adjust the jig's height so it doubles as a depth stop in case you're not drilling all the way through the part.